What are the Clinical Implications of Sarcoglycans?
Mutations in sarcoglycan genes can lead to a group of inherited muscle disorders known as limb-girdle muscular dystrophies (LGMD). These conditions are characterized by progressive muscle weakness and wasting, particularly in the shoulder and pelvic girdles. Understanding the role of sarcoglycans in muscle pathology helps in the development of diagnostic tools and potential therapies for these disorders.
