What Are the Clinical Implications of PDK1 Dysfunction?
Alterations in PDK1 activity are linked to a variety of clinical conditions. Overactivation of PDK1 can lead to uncontrolled cell growth and proliferation, contributing to the development of cancer. Conversely, reduced PDK1 activity can impair cell survival and function, potentially leading to metabolic disorders such as diabetes. Understanding the role of PDK1 in these diseases can aid in the development of targeted therapies.