Abnormalities in motilin secretion or receptor function can lead to various gastrointestinal disorders. For instance, decreased motilin levels or impaired receptor function may result in conditions such as gastroparesis, where the stomach fails to empty properly. Conversely, excessive motilin activity might contribute to disorders involving hypermotility. Studying motilin at the histological level can aid in the diagnosis and treatment of these conditions by identifying pathological changes in the tissue structure and function.