What are the Clinical Implications of MMR Deficiency?
MMR deficiency is a hallmark of Lynch syndrome (Hereditary Nonpolyposis Colorectal Cancer, HNPCC), an inherited condition that significantly increases the risk of developing colorectal and other types of cancer. Identifying MMR deficiency in tumors can guide treatment decisions, as tumors with MMR deficiency often respond differently to certain chemotherapies and immunotherapies.
