What are the Clinical Implications of Loricrin Dysfunction?
Mutations or deficiencies in loricrin can lead to various skin disorders. For example, loricrin keratoderma is a rare genetic condition characterized by thickened skin on the palms and soles. Additionally, alterations in loricrin expression have been observed in diseases such as psoriasis and atopic dermatitis, where the barrier function of the skin is compromised.
