Xbp1 has been implicated in various diseases, particularly those related to ER stress and protein misfolding. For example, in neurodegenerative diseases like Alzheimer's and Parkinson's, dysregulation of the UPR and Xbp1 activity can contribute to disease progression. Additionally, Xbp1 has roles in metabolic disorders, cancer, and inflammatory conditions, making it a significant focus of research in histopathology.
