What are the Clinical Implications of IP3 Receptors?
Dysregulation of IP3 receptor function is associated with several diseases: - Neurological Disorders: Abnormal Ca2+ signaling through IP3 receptors is linked to conditions such as Alzheimer's and Huntington's disease. - Cardiovascular Diseases: Altered IP3 receptor function can impact heart muscle contraction and contribute to arrhythmias and heart failure. - Cancer: Changes in Ca2+ signaling pathways, including those involving IP3 receptors, are implicated in the proliferation and survival of cancer cells.