What are the clinical implications of E1 dysfunction?
Dysfunctions in E1 can lead to a variety of clinical conditions. For example:
Cancer: Aberrant E1 activity can lead to uncontrolled cell proliferation due to the misregulation of cell cycle proteins. Neurodegenerative diseases: Defects in protein degradation pathways, including E1, are linked to conditions such as Alzheimer's and Parkinson's disease. Autoimmune disorders: Improper ubiquitination can result in the malfunction of immune signaling pathways.
Understanding the role of E1 in these diseases can help in the development of targeted therapies.
