What are the Clinical Implications of Basal Lamina Dysfunction?
Dysfunction of the basal lamina can lead to various pathological conditions:
1. Kidney Diseases: Abnormalities in the basal lamina of the glomerulus can result in conditions like Alport syndrome. 2. Muscular Dystrophies: Defects in basal lamina components surrounding muscle cells can cause muscle weakness and degeneration. 3. Cancer Metastasis: Alterations in the basal lamina can facilitate tumor cell invasion and spread.
