What Are the Challenges in Histological Studies of Neurodegeneration?
Despite the advances in histological techniques, several challenges remain:
Post-mortem tissue availability: Access to high-quality post-mortem brain tissue is limited, hindering research efforts. Heterogeneity of disease: Neurodegenerative diseases show significant variability in pathology, making it difficult to draw generalized conclusions. Technical limitations: Some histological techniques lack the resolution needed to observe early cellular changes.
