What are the Cellular Responses to Double Strand DNA Breaks?
Cells have evolved multiple mechanisms to repair DSBs. The two primary pathways are non-homologous end joining (NHEJ) and homologous recombination (HR). NHEJ is a quicker but error-prone process that directly ligates the broken ends, while HR is a more accurate method that uses a homologous template for repair. The choice of pathway depends on the cell cycle stage and the availability of a sister chromatid.
