myocardial stiffness

What are the Cellular Mechanisms Behind Myocardial Stiffness?

Several cellular mechanisms contribute to myocardial stiffness:
Fibrosis: The excessive formation of fibrous connective tissue.
Inflammation: Chronic inflammation can lead to ECM remodeling and increased stiffness.
Oxidative Stress: Damage caused by reactive oxygen species (ROS) can impair cellular function and promote fibrosis.
Calcium Handling: Abnormalities in calcium homeostasis can affect cardiomyocyte contraction and relaxation, influencing stiffness.

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