What are the Cellular Changes During Endothelial Activation?
When endothelial cells are activated, they undergo several cellular changes: - Increased expression of adhesion molecules such as ICAM-1, VCAM-1, and E-selectin. - Upregulation of chemokines like MCP-1 and IL-8. - Altered permeability to allow immune cells to transmigrate. - Pro-thrombotic state due to the expression of tissue factor and reduced anticoagulant properties.
