endothelial activation

How is Endothelial Activation Studied in Histology?

Histological studies of endothelial activation often involve:
- Immunohistochemistry: To detect the expression of activation markers like ICAM-1, VCAM-1, and E-selectin.
- Electron microscopy: To observe ultrastructural changes in endothelial cells.
- In situ hybridization: To localize mRNA expression of specific genes involved in activation.
- Fluorescence microscopy: To visualize changes in cell permeability and junctional proteins.

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