Cross linking has numerous applications in histology:
1. Tissue Fixation: Preserves the structural integrity of tissues for light and electron microscopy. 2. Immunohistochemistry: Stabilizes antigens and improves the binding of antibodies to their targets. 3. In Situ Hybridization: Retains nucleic acid structures for the detection of specific DNA or RNA sequences. 4. Cryosectioning: Enhances the mechanical properties of frozen tissues, making them easier to section.
