MALDI offers several advantages in histology, including: 1. Minimal Sample Preparation: The technique requires minimal sample preparation, preserving the native state of the biomolecules. 2. High Sensitivity: MALDI can detect low-abundance biomolecules, making it suitable for analyzing complex tissue samples. 3. Spatial Resolution: When combined with imaging mass spectrometry (IMS), MALDI allows for the spatial mapping of biomolecules within tissue sections, providing insights into the distribution of proteins and peptides.
