Spinocerebellar ataxias (SCAs) are a group of genetically heterogeneous disorders characterized by progressive ataxia, often with additional neurological symptoms. These disorders primarily affect the cerebellum and its associated pathways, leading to a wide range of motor and non-motor symptoms. Histologically, SCAs are marked by the degeneration of Purkinje cells, granular cells, and other neuronal populations in the cerebellum.
