What are Some Key Metabolic Enzymes and Pathways in Tumors?
Several key enzymes and pathways are often upregulated in cancer cells: 1. Hexokinase 2 (HK2): This enzyme catalyzes the first step of glycolysis and is frequently overexpressed in tumors. 2. Pyruvate Kinase M2 (PKM2): This isoform of pyruvate kinase is involved in the final step of glycolysis and can be regulated to support anabolic processes. 3. Glutaminolysis: Tumors often increase the uptake and metabolism of glutamine to support their growth and proliferation. 4. Fatty Acid Synthesis: Enhanced lipogenesis is a common feature of many cancers, providing the necessary lipids for membrane synthesis and signaling.
