How Can Tumor Metabolism Be Targeted for Cancer Therapy?
Targeting tumor metabolism offers a promising approach for cancer therapy. Strategies include: 1. Inhibiting Glycolysis: Drugs like 2-deoxyglucose can inhibit glycolysis, starving cancer cells of energy. 2. Targeting Metabolic Enzymes: Inhibitors of specific enzymes like HK2 or PKM2 can disrupt the metabolic pathways crucial for tumor growth. 3. Modulating the Tumor Microenvironment: Altering the availability of nutrients and oxygen can affect tumor metabolism and growth.
