sarcoplasmic reticulum:

What are Some Disorders Associated with the Sarcoplasmic Reticulum?

Dysfunction in the SR can lead to various muscle disorders. For instance, malignant hyperthermia is a genetic disorder linked to mutations in the ryanodine receptor, a key Ca2+ release channel in the SR. Similarly, cardiomyopathies may arise from defects in SR Ca2+ handling, leading to impaired cardiac function.

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