What are Some Common CTDs and Their Histological Features?
There are several CTDs, each with unique histological features. Some of the most common include:
- Rheumatoid Arthritis (RA): This autoimmune disorder primarily affects the joints. Histologically, RA is characterized by chronic inflammation, pannus formation, and erosion of cartilage and bone. - Systemic Lupus Erythematosus (SLE): SLE can affect multiple organ systems. In the skin, histology may reveal a thickened basement membrane, immune complex deposition, and inflammation. - Scleroderma: This condition leads to hardening and tightening of the skin and connective tissues. Histologically, it is characterized by excessive collagen deposition, leading to fibrosis. - Marfan Syndrome: This genetic disorder affects connective tissues throughout the body. Histological examination often reveals abnormalities in elastic fibers, particularly in the aorta.
