What are Some Challenges in Histological Assessment of Toxicological Effects?
While histological assessment is invaluable, it faces several challenges:
Sample Preparation: Proper fixation, embedding, and sectioning are critical for preserving tissue morphology and avoiding artifacts. Interpreting Results: Distinguishing between normal and pathological changes can be difficult, especially in complex tissues with inherent variability. Sensitivity and Specificity: Some changes may be subtle or occur at the molecular level, requiring advanced techniques for detection.
