Pancreatic neuroendocrine tumors (PanNETs) are a rare subset of tumors arising from the endocrine tissues of the pancreas. Unlike the more common pancreatic adenocarcinomas, which originate from exocrine cells, PanNETs develop from cells that produce hormones like insulin and glucagon. These tumors can be functional, secreting hormones causing clinical syndromes, or non-functional, not associated with hormone secretion.
