There are several examples of irreversible changes in histology, including:
1. Necrosis: This is a form of cell injury which results in the premature death of cells in living tissue by autolysis. The changes that occur in necrosis are irreversible and lead to cell death. 2. Apoptosis: Although apoptosis is a programmed and controlled process, once a cell has committed to apoptosis, the changes are irreversible and lead to cell death. 3. Fibrosis: This involves the excessive accumulation of connective tissue, leading to scarring. Once fibrosis has set in, the normal architecture of the tissue cannot be restored. 4. Infarction: This occurs when blood supply to a tissue is blocked, leading to tissue death. The damage is irreversible if the blood supply is not quickly restored.
