Enhancing depth penetration can be achieved through various methods:
1. Use of Longer Wavelengths: Employing imaging techniques that utilize longer wavelengths can improve depth penetration. 2. Tissue Clearing: Clearing agents like CLARITY, CUBIC, and Scale can render tissues more transparent, thus enhancing depth penetration. 3. Adaptive Optics: Utilizing adaptive optics can correct for aberrations and improve image quality at greater depths. 4. Advanced Imaging Techniques: Techniques such as multiphoton microscopy and light-sheet microscopy inherently offer better depth penetration.