vascular permeability

How is Vascular Permeability Regulated?

Vascular permeability is tightly regulated by a balance of pro-permeability and anti-permeability signals. Key regulators include:
VEGF (Vascular Endothelial Growth Factor) - A potent pro-permeability factor
Angiopoietins - Modulate the stability and permeability of blood vessels
Tight junction proteins - Maintain endothelial barrier function
Integrins - Mediate endothelial cell adhesion
Nitric Oxide - A molecule that can both increase and decrease permeability

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