How is the role of TNF in cancer addressed in histology?

In the context of cancer, TNF has a dual role. It can promote tumor growth by inducing inflammation and angiogenesis, or it can aid in tumor destruction by activating immune cells. Histological examination helps to identify these dual effects by analyzing tumor tissue and the surrounding microenvironment. Anti-TNF therapy's impact on cancer is complex and requires careful histological evaluation to understand its benefits and risks.