What are the Key Histological Features of Malignancy?
Several histological features are indicative of malignancy, including:
Hyperchromatism: Darkly stained nuclei due to increased DNA content. Pleomorphism: Variation in size and shape of cells and nuclei. High mitotic rate: Increased number of cells in mitosis, often with atypical mitotic figures. Loss of tissue architecture: Disruption of the normal organization of cells and extracellular matrix. Invasion: Penetration of cancer cells into surrounding tissues.
