Ribosome biogenesis is a highly regulated process that responds to the cell’s metabolic state and environmental conditions. Key regulatory mechanisms include:
Transcriptional Control: Regulation of rRNA gene transcription by RNA polymerase I. Post-Transcriptional Modifications: Regulation of rRNA processing and modification by snoRNAs and associated proteins. Protein Import: Regulation of the import of ribosomal proteins into the nucleus. Nuclear Export: Control of the export of ribosomal subunits to the cytoplasm.
