How is Pyknosis Identified in Histological Sections?
To identify pyknotic nuclei in histological sections, tissue samples are typically stained using hematoxylin and eosin (H&E). Pyknotic nuclei appear as small, dark blue to black dots due to the high affinity of condensed chromatin for hematoxylin. The distinct morphological appearance makes it relatively straightforward to identify pyknotic cells under a light microscope.