How is Polycythemia Vera Diagnosed Histologically?
Histological examination of bone marrow is crucial for diagnosing PV. A bone marrow biopsy shows hypercellularity with trilineage growth (erythroid, myeloid, and megakaryocytic proliferation). Additionally, the presence of large, clustered megakaryocytes supports the diagnosis. Special stains and tests, such as JAK2 mutation analysis, are often used to confirm the diagnosis.
