The process of pelleting typically involves the following steps: 1. Sample Preparation: Homogenize the biological tissue to obtain a uniform suspension. 2. Centrifugation: Subject the suspension to high-speed centrifugation. The centrifugal force causes the denser particles to sediment at the bottom of the tube, forming a pellet. 3. Supernatant Removal: Carefully decant or pipette off the supernatant without disturbing the pellet. 4. Pellet Resuspension: Depending on the experimental needs, the pellet may be resuspended in an appropriate buffer or medium for further analysis.