Oxygen sensitivity is studied using various histological techniques: - Histochemical Staining: Stains such as Hematoxylin and Eosin (H&E) can reveal cellular and tissue architecture. - Immunohistochemistry: This technique uses antibodies to detect specific proteins like HIFs, providing insights into cellular responses to oxygen. - Electron Microscopy: Offers high-resolution images of cellular structures, including mitochondria and other organelles affected by oxygen levels.