How is Muscle Fiber Necrosis Identified in Histology?
Under a microscope, necrotic muscle fibers show a variety of changes. These include loss of cross-striations, increased eosinophilia (pink staining with eosin), fragmentation, and infiltration by inflammatory cells. The presence of macrophages and neutrophils around the damaged fibers is also common. Advanced necrosis may lead to complete dissolution of muscle fibers.
