How is MMR Deficiency Detected in Histological Samples?
Detection of MMR deficiency in histological samples typically involves: 1. Immunohistochemistry (IHC): This technique uses antibodies to detect MMR proteins in tissue sections. A lack of staining indicates a deficiency. 2. Microsatellite Instability (MSI) Testing: MSI testing involves analyzing short, repetitive DNA sequences. High levels of MSI indicate a defect in the MMR system. 3. Genetic Testing: Sequencing of MMR genes can identify mutations that result in MMR deficiency.
