MCHC is calculated using the formula: \[ \text{MCHC} = \frac{\text{Hemoglobin (Hgb)}}{\text{Hematocrit (Hct)}} \times 100 \] Where hemoglobin is the amount of the protein in the blood and hematocrit is the volume percentage of RBCs in blood. This formula helps determine the density of hemoglobin within the red blood cells.
