The diagnosis of IPF requires a combination of clinical, radiological, and histological evaluations. Histologically, the presence of usual interstitial pneumonia (UIP) pattern is crucial. The UIP pattern includes:
- Patchy involvement of lung parenchyma with alternating areas of normal lung, interstitial inflammation, and fibrosis. - The presence of fibroblastic foci and honeycombing changes. - A lack of significant granulomas or extensive lymphoid hyperplasia, which helps differentiate it from other interstitial lung diseases.
