Glycogenolysis is tightly regulated by hormonal signals. Glucagon and epinephrine are the primary hormones that stimulate glycogenolysis. They activate cyclic AMP (cAMP) pathways, leading to the activation of protein kinase A (PKA), which in turn activates glycogen phosphorylase. Conversely, insulin inhibits glycogenolysis by activating pathways that dephosphorylate and deactivate glycogen phosphorylase.
