GFR is tightly regulated by various mechanisms to ensure stable kidney function. Autoregulation mechanisms such as the myogenic response and tubuloglomerular feedback help maintain a consistent GFR despite fluctuations in systemic blood pressure. Additionally, hormones like angiotensin II and atrial natriuretic peptide (ANP) play significant roles in modulating GFR by affecting the tone of the afferent and efferent arterioles.
