Ferritin storage is regulated at both the transcriptional and post-transcriptional levels. The iron response element (IRE) and iron regulatory proteins (IRPs) play significant roles in modulating ferritin synthesis in response to cellular iron levels. When iron levels are high, IRPs are inactivated, allowing for the translation of ferritin. Conversely, low iron levels activate IRPs, which bind to IREs and inhibit ferritin translation.
