Drug delivery faces several challenges, many of which are related to histological factors:
Tissue Permeability: Some tissues, such as the blood-brain barrier, have low permeability, making it difficult for drugs to reach their target site. Drug Metabolism: Enzymes present in specific tissues can metabolize the drug before it reaches its intended target, reducing its effectiveness. Immune Response: Certain cellular structures can trigger an immune response, leading to the rapid clearance of the drug from the body. Target Specificity: Achieving high specificity in targeting only the diseased tissue without affecting healthy tissue is challenging. Drug Stability: The histological environment can affect the stability of the drug, leading to its degradation before it can exert its therapeutic effect.
