ERBB2 detection in histological samples is typically performed using immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). IHC involves the use of antibodies that specifically bind to the ERBB2 protein, allowing for visualization under a microscope. FISH, on the other hand, uses fluorescent probes that bind to the ERBB2 gene loci, helping to identify gene amplification.
