ER stress is implicated in the pathology of various diseases: - Diabetes Mellitus: ER stress in pancreatic beta cells can lead to insulin deficiency and hyperglycemia. - Alzheimer's Disease: Accumulation of misfolded proteins and ER stress are hallmarks of this neurodegenerative disorder. - Cancer: Tumor cells often experience ER stress due to rapid growth and hypoxic conditions, which can influence tumor progression and resistance to therapy.
