Dysregulation of E2 enzymes can lead to various diseases, including cancer, neurodegenerative disorders, and inflammatory conditions. For instance, mutations or aberrant expression of E2 enzymes have been linked to the pathogenesis of cancer due to their ability to affect the stability of oncogenes and tumor suppressor proteins. Additionally, improper function of E2 enzymes has been implicated in neurodegenerative diseases like Parkinson's and Alzheimer's, where protein aggregation is a hallmark.
