Alterations in caveolin 1 expression or function are associated with various diseases. Overexpression of caveolin 1 has been linked to cancer progression, especially in breast cancer and prostate cancer. Conversely, reduced levels are observed in pulmonary hypertension and cardiovascular diseases. Additionally, mutations in the caveolin 1 gene can lead to congenital generalized lipodystrophy, a disorder characterized by a lack of adipose tissue.
