Diagnosis of ABPA involves a combination of clinical, radiological, and immunological criteria. Histological examination of lung tissue can be highly indicative, particularly when combined with other diagnostic tools such as:
Radiographic imaging (e.g., chest X-rays or CT scans) to identify bronchiectasis and mucus plugging. Serological tests to detect elevated levels of IgE antibodies specific to Aspergillus antigens. Sputum culture to identify the presence of Aspergillus species.