Histological examination is the gold standard for identifying abnormal tissue architecture. This involves the microscopic analysis of tissue sections stained with various dyes. Techniques such as Hematoxylin and Eosin (H&E) staining, immunohistochemistry, and special stains are commonly used. These methods help to highlight differences in cell morphology, tissue organization, and the presence of abnormal structures like necrosis and fibrosis.
