How Does the Extracellular Matrix Contribute to Intrinsic Repair?
The extracellular matrix (ECM) provides structural support to tissues and is a reservoir for growth factors that aid in repair. During intrinsic repair, the ECM undergoes remodeling to accommodate new tissue formation. Enzymes like matrix metalloproteinases (MMPs) degrade damaged ECM components, while fibroblasts produce new ECM proteins such as collagen and elastin.