Serotonin influences tissue interaction by binding to its receptors, which are distributed in various tissues. These receptors are classified into different types, such as 5-HT1, 5-HT2, and 5-HT3, each mediating distinct physiological responses. For example, 5-HT3 receptors in the gastrointestinal tract mediate secretion and motility, while 5-HT1 receptors in the CNS are involved in mood regulation.