How does Reorganization Differ in Normal and Pathological Conditions?
In normal conditions, reorganization is a tightly regulated process that maintains tissue homeostasis. For example, during wound healing, cells proliferate and migrate to close the wound, followed by ECM remodeling to restore tissue structure. In contrast, pathological conditions can disrupt this balance:
Cancer: In cancer, uncontrolled cell proliferation and altered cell signaling disrupt normal tissue architecture. Fibrosis: Excessive ECM production and deposition can lead to tissue stiffening and impaired function. Inflammation: Chronic inflammation can result in persistent tissue damage and aberrant reorganization.
